Work in Dr. Schaefers laboratory addresses the epigenetic basis of neurodegenerative and psychiatric disorders. We study how miRNAs and histone modifying enzymes contribute to the establishment and maintenance of neuronal identity and specialized functions. We are particularly interested in understanding the epigenetic mechanisms of cellular plasticity and its role in regulation of microglia-neuron communication. Using pioneering technologies including cell type specific analysis of mRNAs, miRNAs and chromatin modifications in neurons in vivo, our research aims at understanding the mechanism of neurological disorders and at their potential treatment by targeting the neuronal epigenome.
This postdoctoral project aims at understanding the role of cognate microglia-neuron interaction upon neuronal activation and neuronal stress induction. Job Qualifications Candidates should have a Ph.D. in Neuroscience, with extensive experience in the biochemistry of RNA transcription, RNA translation and chromatin. They should be highly motivated and be able to work both independently and as part of a team. Experience with FACS-sorting, RNA and DNA purification, TRAP analysis, ribosomal RNA footprinting, and genome wide analysis, molecular cloning, and cell culture techniques are especially desirable.
Mentoring and training of less experienced staff will be part of the responsibilities.
Minimum Computer Skills
Microsoft office with Word, Excel, Powerpoint, Adobe Illustrator, Photoshop, Preview, Image J, TreeView,IGV Browser, Prism, Ingenuity, Avadis, and Genespring