Work in Dr. Schaefer's laboratory addresses the epigenetic basis of neurodegenerative and psychiatric disorders. We study how miRNAs and histone modifying enzymes contribute to the establishment and maintenance of neuronal identity and specialized functions. We are particularly interested in understanding the epigenetic mechanisms of cellular plasticity and its role in regulation of microglia-neuron communication. Using pioneering technologies including cell type specific analysis of mRNAs, miRNAs and chromatin modifications in neurons in vivo, our research aims at understanding the mechanism of neurological disorders and at their potential treatment by targeting the neuronal epigenome.
This postdoctoral project aims at understanding the role of cognate microglia-neuron interaction and its role in inflammation. Job Qualifications Candidates should have a Ph.D. in Neuroscience, with extensive experience in the biochemistry of chromatin. They should be highly motivated and be able to work both independently and as part of a team. Experience with FACS-sorting, RNA and DNA purification and genome wide analysis, molecular cloning, stereotactic surgery in mice, and cell culture techniques are especially desirable.
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