Job Description

Successful candidates will engage in several projects centered around the analysis of large-scale functional genomics datasets from brain tissue, including next-generation sequencing of ChIP-seq (epigenetic profiling of histone modifications) and RNA-seq (gene expression profiling, isoforms). Work will be conducted under the direction of Dr. Pamela Sklar.

The candidate will join the Division of Psychiatric Genomics in the Departments of Genetics and Genomic Sciences and Psychiatry to develop computational tools and perform data analysis for projects related to the functional characterization of post-mortem human brain tissue at the molecular level, in particular as it relates to schizophrenia and bipolar disorder. Projects will include computational and statistical analysis of functional sequencing studies, working with collaborators in international consortia (CommonMind, PsychENCODE, PGC), statistical methods development and data analyses, and the integration of disease-implicated genetic variation, epigenetic, and gene expression data into pathway and network analyses. Additionally, the individual will be responsible for the organization and integration of these various datasets.

Job requirements:
• PhD in Computational Biology, Bioinformatics, Computer Science, Biology, Biomedical Engineering, Computer Engineering, Genetics or related field
• Experience, with biological datasets and experience with bioinformatics, computational biology, machine learning, and statistics
• Demonstrated experience designing computational methods and tools, including prior experience with algorithms relevant to computational biology, and skill and experience with statistical analysis is strongly preferred
• Experience with software in at least two of these languages on a Linux environment: Python, R, bash, Perl, Java, and C++
• Excellent communication a skills with a focus on teamwork and creating usable and accessible research software tools

High Performance Computing at Mount Sinai
We make extensive use of Mount Sinai’s HPC resources. Our HPC group is dedicated to advancing research at the Icahn School of Medicine at Mount Sinai (ISMMS) by administering a sustainable state-of-the-art computational infrastructure, and providing technology services. Current compute and storage resources exceed 12,000 cores and 10 petabytes of disk. Our HPC provides 140 teraflops peak speed and over 85 million CPU hours per year.

Icahn Institute for Genomics and Multiscale Biology
The Icahn Institute was founded in 2011 to help advance precision medicine with cutting-edge technologies, novel partnerships between the public and private sector, and world-class computational and analytical resources.

About the Psychiatry Department at Mount Sinai
The Division of Psychiatric Genomics is part of the Department of Psychiatry at Mount Sinai, a vibrant community of clinicians, researchers, educators, and trainees committed to discovering the causes of and treatments for mental and emotional disorders. We are ranked among the nation’s top psychiatry departments for funding from the National Institutes of Health.

About the Icahn School of Medicine at Mount Sinai
The Icahn School of Medicine at Mount Sinai is an international leader in medical and scientific training, biomedical research, and patient care. It is the medical school for the Mount Sinai Health System, which includes seven hospital campuses, and has more than 5,000 faculty and nearly 2,000 students, residents and fellows. Our unwavering pursuit of intellectual exchange, breakthrough research, and multidisciplinary teamwork propels us ever forward in biomedical discoveries and advances. We pursue ideas that often challenge conventional wisdom to revolutionize the practice of medicine and produce dramatically better outcomes for patients.

To Apply
Please send your CV and a cover letter to Savannah Lennertz (
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