Mount Sinai Careers
• One position will study the role of a novel transcription factor in promoting lesion repair (remyelination) in models of MS.
• The second position will study mechanisms controlling access of inflammatory cells across the blood-brain barrier into the CNS parenchyma in lesions in MS models.
Core techniques in use in the laboratory include primary culture and co-culture of CNS-resident cell lineages, particularly astrocytes, oligodendrocytes and endothelial cells, genome-scale analyses (RNA-seq and ChIP-seq) of responses of these populations to inflammatory stimuli, and in vivo validation using conditional knockout models and human samples.
Interested candidates should have a recent PhD or MD degree, a strong background in molecular and cellular neurobiology, and good scientific writing skills.