Mount Sinai Careers

POSTDOCTORAL FELLOW

United States
Research


Job Description

The Laserson lab is a new lab focused on developing novel high-throughput technologies for precision immunology. We utilize next-generation sequencing, synthetic biology, and single-cell methods to build platform technologies. Application areas include personalized immunotherapy, gut-immune system interaction, and therapeutic antibody discovery. We are focused on developing practical tools that others can build on and that will translate clinically.

The PI

Uri was born in Tel Aviv and grew up in Miami before studying Math and Biology during college at NYU. He entered the PhD program in the Math department at MIT, after which he joined George Church’s lab at Harvard Med to train in genomics technology development. Uri developed some of the first protocols and software for next-generation sequencing of the antibody repertoire. He also collaborated with Ben Larman to help develop the PhIP-seq assay for high- throughput antigen specificity. During graduate school, Uri cofounded Good Start Genetics, one of the first diagnostics companies to bring NGS to the clinic. After earning his PhD, Uri worked at Cloudera, which builds Hadoop infrastructure for big data. During this time, he became a core member of the ADAM team developing software for scaling genomics analyses to millions of samples. In 2016, Uri joined the genetics faculty at Mt Sinai.

The Job

You will be a founding member of the lab. Together with the PI, you will be responsible for defining your research plan and executing it. Research directions are flexible, but example areas of interest include developing PhIP- seq-style assays for gut-immune interaction (like IgA-seq), single-cell phenotyping with NGS, methods for discovering personalized antibody therapeutics, highly-multiplexed immunohistochemistry. We expect the research program to require proficiency in a variety of experimental techniques, including sample/library prep for sequencing, molecular cloning, tissue culture, antibody assays, and flow cytometry/FACS. Because the lab is new, you will have the opportunity to help build out a new research lab and will also be instrumental in defining the lab culture. You can also assist in training/mentoring graduate students.

 

 

 

We will be utilizing a broad range of cutting-edge techniques, and a willingness to learn and experiment will be crucial. You should have a PhD or equivalent experience in a life sciences field. In addition to the techniques listed above, experience with any of the following would be a plus:

• protein surface display (e.g., phage, yeast, or ribosome display)

• genome editing techniques (e.g., CRISPR)

• synthetic DNA constructs and large oligonucleotide pools

• droplet microfluidics

• single cell methods

• microbiome techniques

• histology/microscopy