Our laboratory seeks to better understand paramyxovirus biology, and to exploit them toward improving human health. While the highly pathogenic and neurotropic BSL4 agent, Nipah virus (NiV), is our lab main focus, we have recently developed new and very powerful reverse genetics systems that enable rescue of any paramyxovirus with high efficiency.
The CHDI FOUNDATION, for a cure for Huntington’s disease, is funding this project. There is a dire need for new and efficient viral vectors able to globally transduce the Central Nervous System (CNS) after non-invasive systemic injection. Our rationale exploits the natural neurotropism of NiV, and leverages our reverse genetics systems, to develop new viral vectors. NiV-pseudotypes will be evaluated in in vitro and in vivo models, for their ability to actively cross the Blood-Brain barrier (BBB) and globally transduce the CNS. Vectors are to be based on both lentivirus and paramyxovirus (Sendai and Newcastle disease viruses) backbones.
The position is open immediately and funded for a minimum of 2 years. Competitive salary is commensurate with experience, and expected to be higher than NIH postdoctoral pay scales. ISMMS is an equal opportunity employer fostering diversity in the workplace, and offers excellent benefits plans and affordable apartments in hospital-owned housing (subject to availability).
Interested applicants should email any questions along with their CV and references, to Prof. Benhur Lee (firstname.lastname@example.org) and Dr. Frederic Vigant (email@example.com).
Applicants must have a PhD, with postdoctoral experience preferred. Experience with modern molecular biology, model system development, cell culture, viral production, and in vivo biodistribution studies is desirable.