The laboratory of neurodegenerative diseases at the Icahn School of Medicine at Mount Sinai (Neurology) seeks a post-doctoral research associate to perform research in the exciting field of neurodegeneration. Candidate should have at least two years of post-doctoral experience and/or five or more first authored publications in peer-reviewed journals. Strong publication record and excellent academic essentials are fundamental. To investigate the brain mechanisms by which mutations in genes cause neurodegeneration, the candidate should be self-motivated and have strong academic training in biochemistry, molecular and cell biology. The candidate will be responsible for conducting, designing, and executing experiments related to the already-generated genomic, exomic, and epigenomic data. Knowledge of genetics, genomics, and related fields is essential, and understanding of bioinformatic approaches for analyzing data from high-resolution genome-wide techniques is desirable. A broad range of molecular and genetic approaches will also be employed in zebrafish models of neurodegeneration; therefore, experience with zebrafish embryos or other small animals is also required. Zebrafish mutants will be generated through the CRISPR-Cas9 technology, so experience in both NHEJ and HDR methods are required.
Candidate should have excellent communication skills and the ability to work in a team and the competence to interact professionally with all levels of staff and faculty. Candidate should be able to work independently and manage multiple independent projects in a timeline-driven environment. Good knowledge of the pathophysiology of parkisnonism and related neurodegenerative diseases is recommended.