Mount Sinai Careers
Associate Researcher II, Oncological Sciences
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The Guccione lab has a long-standing interest in understanding basic mechanisms of transcriptional and post-transcriptional regulation in order to identify therapeutic opportunities in oncology. Currently, we are interested in the function in development and disease of Protein MethylTrasnferases (PMTs) and in modulation of Alternative Splicing using Antisense Oligonucleotide (AON)-based approaches. We use biochemistry, mouse models and next generation sequencing techniques to understand the molecular mechanisms of action of candidate PMTs or specific isoforms.
Duties and Responsibilities:
- Manage a mouse colony and perform animal husbandry as needed. Genotyping, sex identification, weening. Embryo collection and dissection. Paraffin embedding and whole mount ISH.
- Perform bench experiments (tissue culture and molecular biology). More specifically: culture of primary mouse and human organoids in 3D. Preparation of material for ATAC-seq, Chip-seq, RNA-seq and other omic technicques. Cloning, RNA, DNA and Protein quantification and identification techniques. FLA-PCR, RT-qPCR.
- Lab management and ordering. Help to maintain a clean and safe lab environment
- Bachelors or Masters degree in life sciences
- 4 years of experience in bench research
- Background in handling a mouse colony and in lab management
- Experience with primary cell culture and molecular biology techniques is appreciated
- Must have a positive attitude towards team work, and be well organized
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Over 35,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
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