Mount Sinai Careers

Associate Researcher II, Oncological Sciences

New York, New York

Job Description

The Mount Sinai Health System

Do you have what it takes to wear the badge?


The Mount Sinai Health System’s commitment to excellence extends beyond delivering world-class health care. The System’s ongoing success is dependent upon our highly motivated, nonclinical professionals working to improve business operations. Our leadership team is driven to provide exceptional service by cultivating a workforce that is dedicated to upholding Mount Sinai’s mission of delivering innovative, breakthrough medicine with compassion and integrity.


Are you ready to discover the world of limitless possibilities that comes with wearing the badge? Explore more about this opportunity and how you can help us write a new chapter in our story of unrivaled patient care!

What You’ll Do:

The Guccione lab has a long-standing interest in understanding basic mechanisms of transcriptional and post-transcriptional regulation in order to identify therapeutic opportunities in oncology. Currently, we are interested in the function in development and disease of Protein MethylTrasnferases (PMTs) and in modulation of Alternative Splicing using Antisense Oligonucleotide (AON)-based approaches. We use biochemistry, mouse models and next generation sequencing techniques to understand the molecular mechanisms of action of candidate PMTs or specific isoforms.


Duties and Responsibilities:

  • Manage a mouse colony and perform animal husbandry as needed. Genotyping, sex identification, weening. Embryo collection and dissection. Paraffin embedding and whole mount ISH.
  • Perform bench experiments (tissue culture and molecular biology). More specifically: culture of primary mouse and human organoids in 3D. Preparation of material for ATAC-seq, Chip-seq, RNA-seq and other omic technicques. Cloning, RNA, DNA and Protein quantification and identification techniques. FLA-PCR, RT-qPCR.
  • Lab management and ordering. Help to maintain a clean and safe lab environment
What You’ll Bring:
  • Bachelors or Masters degree in life sciences
  • 4 years of experience in bench research
  • Background in handling a mouse colony and in lab management
  • Experience with primary cell culture and molecular biology techniques is appreciated
  • Must have a positive attitude towards team work, and be well organized

Do you share our dedication to extraordinary service and have what it takes to wear the badge? Apply now!

Who We Are:

Over 35,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.


Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.


The Mount Sinai Health System is committed to the tenets of diversity and workforce that are strengthened by the inclusion of and respect for our differences. We offer our employees a highly competitive compensation and benefits package, a 403(b) retirement plan, and much more.


The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation.

EOE Minorities/Women/Disabled/Veterans