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Associate Researcher I, Hematology & Oncology
The Mount Sinai Health System
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An Associate Researcher I positon is currently available within the lab of Dr. Yelena Ginzburg at the Tisch Cancer Institute at the Icahn School of Medicine of Mount Sinai. The lab focuses on iron metabolism and erythropoiesis in health and disease. The Ginzburg laboratory is a team of scientists and student scientists with deep interest in understanding the crosstalk between erythropoiesis and iron metabolism. We are looking for a highly motivated individual with an interest in science to support a research project aimed at understanding in detail how iron transport influences erythropoiesis and how the erythron communicates iron requirements to the liver, the main organ involved in hepcidin production.
To determine the regulatory role of iron transport in erythropoiesis, we aim to utilize standard molecular biology techniques, novel mouse models with mutations in erythropoiesis- and iron-related genes, and state-of-the-art genetic manipulation tools.
Iron transport for erythropoiesis, crosstalk between them, and erythroid regulation of iron metabolism are central tenets in recovery during stress erythropoiesis and are dysregulated in multiple hematological disorders and thus of great interest to the hematology field. The successful completion of this work will provide insight into the pathophysiology of human diseases in which erythropoiesis is disturbed (e.g. β-thalassemia, polycythemia vera, and MDS), extend current knowledge in iron metabolism, and add new paradigms for further exploring erythroid regulation of hepcidin in health and disease.
Under moderate supervision, the person filling this position will be required to conducts routine and standardized experiments using advanced techniques specific to the research project (e.g. microscopy, flow cytometry and cell sorting techniques as well as mouse husbandry). The candidate will also be asked to participate in data analysis and interpretation and presentation at lab meeting, locally within the Mount Sinai academic community, and possibly at national and international meetings.
Duties and Responsibilities:
- *Conducts routine and standardized experiments using advanced research techniques specific to subject matter of the research project as directed by PI and more senior lab staff.
- *Analyzes and assists in interpreting moderately complex results.
- *Performs assays to support research studies.
- *Assists in new and unexpected research experiments and techniques.
- *Assists in the collection, analysis and review of experimental data for publication and presentation.
- * Maintains good records and contact with collaborators where appropriate.
- * Learns and masters computer and technical skills necessary for experimental execution as well as data input and analysis.
- Performs other related duties as assigned.
*-indicates duty is “essential” as defined by the Americans with Disabilities Act (ADA)
- Bachelor’s Degree in science or related field preferred or equivalent experience.
- Excellent organizational, problem solving and analytical skills
- Excellent verbal, written and interpersonal communication skills
- Knowledge of standard research concepts
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Over 35,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
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The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation.