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Trainee, Pharmacological Sciences
Ground breaking science. Advancing medicine. Healing made personal.
Our lab is currently conducting a computational and experimental study to compare Ca2+ sparks in cardiac myocytes with the analogous Ca2+ puffs in Xenopus oocytes. Sparks and puffs are stochastic cellular events that reflect release of Ca2+ through clusters of channels in the ER/SR membranes. Both of these phenomena are triggered by smaller events where individual channels open and can lead to larger events where Ca2+ waves propagate across an entire cell.
This spontaneous cell-wide Ca2+ release acts as a pathological signal in cardiac myocytes but as a necessary physiological signal in oocytes. Although sparks and puffs have been extensively investigated both experimentally and computationally, it is still not well understood what differential mechanisms between sparks and puffs influence these divergent cell-wide physiological and pathological outcomes. We hypothesize that these differences can be understood by using quantitative analyses. For this project, summer undergraduate students will assist in:
- Performing stochastic simulations of Ca2+ puffs and Ca2+ sparks from release units with different fundamental properties
- Using parameter sensitivity analysis to quantify how different molecular-level biological variables influence the observed event heterogeneity
- Studying the relationship between Ca2+ spark and Ca2+ puff transitions from local events to cell-wide Ca2+ waves
- Verifying modeling predictions experimentally
- Must be currently enrolled in an undergraduate biomedical engineering program
- Strong quantitative background and some exposure to MATLAB
- No prior research experience is required; however, we expect the students to be motivated to do research and enthusiastic about strengthening their quantitative and computational skills
The Mount Sinai Health System believes that diversity is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize medicine together.
We work hard to acquire and retain the best people, and to create a welcoming, nurturing work environment where you can develop professionally. We share the belief that all employees, regardless of job title or expertise, can make an impact on quality patient care.
Explore more about this opportunity and how you can help us write a new chapter in our story!
Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation.