Mount Sinai Careers

Senior Scientist, Department of Psychiatry - Seaver Autism Center for Research and Treatment

New York, New York

Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

Roles & Responsibilities:

The Seaver Autism Center for Research and Treatment (the “Center”) is a fully integrated translational research center dedicated to discovering the biological causes of autism and developing breakthrough treatments. Our mission is to enhance the diagnosis of autism and related disorders, discover the biological causes of those disorders, and develop and disseminate breakthrough treatments. We strive to bridge the gap between new discoveries in basic science and enhanced care, while ensuring the community is aware of new and improved approaches to caring for people with ASD.


The Director of Drug Discovery and Development at the Seaver Autism Center (“Director”) provides scientific and technical leadership in the management, design and execution of the program.  With a broad range of skills and experience, this individual is a critical component of the Center, demonstrating a capacity for collaboration and innovation with consistently high productivity. S/he will oversee all the staff in the program and is responsible for oversight of the program’s budget, reporting to the Center Director and Administrative Director.


The Director provides informed decision making in the discovery of biomarkers and development of therapeutic targets, including project planning, experimental protocols and procedures, and oversight of day-to-day unit operations. S/he takes lead role in developing and conducting collaborations with industry representatives. S/he is responsible for designing protocols, establishing benchmarks and deliverables, and will participate in contract negotiations and intellectual property determinations. S/he engages in human in vitro and animal model-based in vivo research to use disease associated genetic variation to explore novel targets.


Duties and Responsibilities:

  • Develops, adapts and performs new and established experimental protocols and techniques. Plans and implements research projects in biomarker analysis and therapeutic development using human and murine model-based research. Work with computational and bioinformatics scientists to organize data collection, integration and analysis. Use knowledge of target-focused, pathway-focused, and phenotypic assays, as well as secondary assays to confirm and determine the mechanism of action.
  • Develops new models, oversees maintenance of animal colonies and in in vivo experimentation.
  • Explores subject area and defines scope and selection of problems for investigation through conceptually related studies.
  • Develops hypotheses to be tested and methodology for evaluating results.
  • Engages computational and bioinformatics scientist for data, product and outcomes optimization, integration and analysis.
  • Makes decisions and recommendations that have a major impact on extensive scientific research activities.
  • Manages day-to-day lab operations. Act as lab manager, including financial management, budgetary compliance, and human resources responsibilities.
  • Directs research team including post-doctoral researchers, research associates and other lab personnel. Supervise and train post-doctoral researchers, research associates and lab assistants. Develop work plan, devise experiments, identify techniques and approaches, oversee progress, and evaluate results. Ensure that optimal timelines are set and met.
  • Ensure appropriate training of research unit personnel and investigators in sample handling and processing in relation to biomarkers assays. Maintain strict adherence to research compliance regulatory standards for human and animal subjects use.
  • Identifies potential industry and academic partners. Develops and maintains partnerships with industry and academic entities to deliver a robust biomarker/target discovery platform. Uses target biology expertise and chemistry knowledge for strategy and method development and validation of new assays, as well as technology transfer to internal and external partners.
  • Support Business Development activities through active participation in presentations to potential investors, support and brainstorming with business partners for the ongoing development of appropriate business plans, and management of intellectual property arising from research.  Expected to develop and maintain strong relationship with Mount Sinai Innovations Partners and associated business partners.
  • This position will work in a laboratory environment.
  • Performs other related duties.
  • PhD or MD/PhD in neuroscience, genetics, molecular biology or related field.
  • Extensive cell biology, biochemistry and molecular biology experience. Strong theoretical understanding of biomarkers and therapeutic target discovery. Strong theoretical and practical knowledge in neuroscience.
  • Minimum five years of experience with scientific investigation, with progressive responsibility, including management of teams and project budgets.
  • Must have demonstrated outstanding achievement in a field of research.
  • Must have contributed to a number of peer-reviewed publications, inventions or the like, at least some of which have had a major impact on advancing the field or discipline.
  • Industry experience is desirable and preferred.
  • Ability to work independently or as part of a team and be able to communicate clearly and concisely, both orally and in writing.
  • Excellent written and oral communication skills.
  • Exceptional attention to detail and accuracy.
Strength Through Diversity

The Mount Sinai Health System believes that diversity is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize medicine together.


We work hard to acquire and retain the best people, and to create a welcoming, nurturing work environment where you can develop professionally. We share the belief that all employees, regardless of job title or expertise, can make an impact on quality patient care.


Explore more about this opportunity and how you can help us write a new chapter in our story!

Who We Are

Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.


Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.


The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation. 


EOE Minorities/Women/Disabled/Veterans

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