The postdoctoral fellow will conduct research into mechanisms that regulate cell survival versus cell death in cells. He will study how ubiquitination of key signaling molecules in the TNF pathway determines cell fate and how this plays a role in cancer development. The goal is to identify cellular proteins that could serve as therapeutic targets in sensitizing cancer cells to immune-mediated destruction. This would involve generating genetically-modified cell lines and mice, characterizing these reagents and studying how these genetic manipulations alter the ability of cells to survive/die and their susceptibility to lymphocyte-mediated cytotoxicity.
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