Mount Sinai Careers
Associate Researcher, Department of Psychiatry, The Seaver Autism Center for Research and Treatment
Ground breaking science. Advancing medicine. Healing made personal.
An Associate Researcher position is available in the Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai (ISMMS) in New York City.
The Seaver Autism Center for Research and Treatment is a fully integrated translational research center dedicated to discovering the biological causes of autism spectrum disorder (ASD) and other neurodevelopmental disorders and developing breakthrough treatments. Our mission is to bridge the gap between new discoveries at the basic science level and clinical care by developing new and improved approaches to autism diagnosis and treatment. Our interdisciplinary patient-based research team includes psychiatrists, psychologists, neurologist, clinical geneticist, and trainees in medicine and psychology. The Seaver Autism Center is committed to serving individuals of all levels of functioning and takes a unique genetics-first approach to autism research. Investigators at the Seaver Center have strong collaborations with the Departments of Psychiatry, Neuroscience and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. We also collaborate with several other institutions, nationally and internationally.
Neuronal precursors and neurons derived from human induced pluripotent stem cells (iPSCs) have become a valuable model of neurodevelopmental disorders, complementing research studies in animal models. The Seaver Autism Center for Research and Treatment develops iPSCs to investigates neural and molecular mechanisms underlying the pathogenesis of autism, with the goal to 1) generate library of iPSCs and iPSC-derived neuronal cells for several neurodevelopmental disorders; 2) characterize iPSC-derived neuronal cells from patients and controls to identify altered pathways and cellular phenotypes that can be targeted for the development of novel therapeutics; 3) provide a unique platform for drug discovery, allowing high-throughput screening of large compounds libraries.
The Associate Researcher is an entry level laboratory research position, responsible for conduct of routine and standardized experiments under the supervision of the Principal Investigator or a senior researcher. He/she will be involved in the generation and the maintenance of the iPSC lines and other duties as needed.
Duties and responsibilities:
- Reprogramming human somatic cell lines into induced pluripotent stem cells (iPSCs).
- Maintaining iPSCs in culture.
- Differentiating iPSCs into different populations of brain cells using 2D and 3D cellular models.
- Quality control of generated iPSCs and iPSC-derived cells.
- Banking and preparing iPSCs and iPSC-CMs for distribution.
- Molecular biology experiments.
- Maintaining inventory and ensuring equipment maintenance.
- Educating other personnel in cell culture techniques.
- Assist in the collection, analysis and review of experimental data for publication and presentation.
- Participate in biweekly meetings of the lab as well as other scientifically-oriented meetings, seminars, and related activities.
- Performs other related duties.
- Bachelor’s Degree in Neuroscience, Neurobiology or a related discipline or combination of relevant research experience and education
- 0-2 years of research/laboratory experience
- This position requires actual hands-on knowledge in cellular and molecular neuroscience approaches. This position also requires expertise and experience in cell culturing, molecular biology techniques, immunofluorescence microscopy, cellular cryopreservation, molecular cloning and gene expression analysis such as real-time polymerase chain reaction (RT-PCR). Preferred applicants will have additional work experience with iPSC reprogramming and differentiation
- Knowledge in R or other languages for statistical computing or graphics is a plus.
- Familiarity with Photoshop and Illustrator is a plus
- Excellent organizational, problem solving and analytical skills
- Highly motivated and have the ability to work both independently and in a multidisciplinary team-oriented environment
- Excellent verbal, written and interpersonal communication skills
- Ability to multi-task, set priorities and pay close attention to detail
- Knowledge of standard research concepts
- Experience with and understanding of molecular techniques, especially cell culture, DNA/RNA/Protein Isolation, western blot analysis, PCR, and cloning
The Mount Sinai Health System believes that diversity is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize medicine together.
We work hard to acquire and retain the best people, and to create a welcoming, nurturing work environment where you can develop professionally. We share the belief that all employees, regardless of job title or expertise, can make an impact on quality patient care.
Explore more about this opportunity and how you can help us write a new chapter in our story!
Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation.