Analysis of Alzheimer’s Disease mouse model to investigate function of the neuronal protein VGF in the pathogenesis and progression of this disease, and determination of the efficacy of AAV-VGF gene therapy to reduce amyloidosis and tauopathy in mice. Duties will include mouse colony maintenance and genotyping, stereotactic surgery including AAV delivery and cannula implantation, protein and RNA preparation for western, PCR and/or transcriptomics analysis, immunohistochemical analysis, and mouse behavioral analysis (memory, depression, anxiety, and/or feeding and body weight analysis).
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