POSTDOCTORAL FELLOW

Job Description

Job Opportunities Roussos Laboratory (Panos Roussos, MD, PhD) at the Pamela Sklar Division of Psychiatric Genomics (DPG) in Icahn School of Medicine at Mount Sinai (ISMMS)

 

    Post-doctoral Fellow in Statistical and Computational Genomics

 

A position at the Roussos Lab/Pamela Sklar Division of Psychiatric Genomics (DPG) in Icahn School of Medicine at Mount Sinai is available for a Postdoctoral Fellow in Statistical and Computational Genomics. The post will suit an ambitious and talented individual who is interested in applying his/her skills at the interface of human disease and genetics.

 

The appointed researcher will be embedded in an interdisciplinary team of clinicians, wet lab scientists, bioinformaticians, statistical geneticists and computational biologists. The Roussos Lab/Pamela Sklar Division of Psychiatric Genomics studies the genetic mechanisms through which risk genetic variants increase vulnerability for neuropsychiatric traits, including schizophrenia, bipolar disorder and Alzheimer’s disease. Distinguishing features of our research are the generation of large-scale omics data in human brain tissue, including epigenomics and transcriptomics and the use of genome sequencing for big data integration. As part of the Million Veteran Program (https://www.research.va.gov/mvp/), an initiative in Precision Medicine by the Department of Veteran Affairs, we are performing integrative analysis of functional omics data (transcriptomics and epigenomics) with genotypes and clinical data in one million individuals. The successful candidate will be primarily responsible for: (1) computational analyses of whole-genome/exome sequencing datasets and genome-wide SNP array, with the aim to characterize different classes of sequence and genotyping variants; (2) modeling the genetic architecture from sequencing and genome-wide SNP data with aim to compare traits across molecular pathways and functional omics data derived from multiple tissues/cell types; and (3) integrate SNP predictors of omics data with large-scale biobank datasets, such as MVP to identify molecular targets and pathways affected across multiple traits.


Job requirements:

•    PhD in Statistics, Biostatistics, Statistical Genetics, Genetic Epidemiology, or related discipline are required.

•    Firm grounding in statistical methods for genome data analysis.

•    Experience with biological datasets and next generation sequencing data.

•    Experience analyzing large-scale genetic datasets in complex human traits or disease and using main statistical packages for genetic data (e.g. GCTA and SNPtest).

•    Experience working with large publically available databases (eg. 1000 Genomes, UK10K, ExAC, gnomAD, HGMD, TCGA, COSMIC, etc.).

•    Outstanding programming skills in at least two of these languages on a Linux environment: Python, R, bash, Perl, Java, and C++.

 

Job requirements:

•    PhD in Statistics, Biostatistics, Statistical Genetics, Genetic Epidemiology, or related discipline are required.

•    Firm grounding in statistical methods for genome data analysis.

•    Experience with biological datasets and next generation sequencing data.

•    Experience analyzing large-scale genetic datasets in complex human traits or disease and using main statistical packages for genetic data (e.g. GCTA and SNPtest).

•    Experience working with large publically available databases (eg. 1000 Genomes, UK10K, ExAC, gnomAD, HGMD, TCGA, COSMIC, etc.).

•    Outstanding programming skills in at least two of these languages on a Linux environment: Python, R, bash, Perl, Java, and C++.


•    Track record of delivering complex scientific projects through high impact factor publications.

•    Excellent  communication  and  organizational  skills  with  ability  to  work  to  tight  timelines,  both independently and as part of a multi-disciplinary team.

 

 

 

High Performance Computing (HPC) at ISMMS

Our HPC group is dedicated to advancing research at the ISMMS by administering a sustainable state-of-the- art computational infrastructure and providing technology services. Current compute and storage resources exceed 12,000 cores and 10 petabytes of disk. Our HPC provides 140 teraflops peak speed and over 85 million CPU hours per year.

 

About the Pamela Sklar Division of Psychiatric Genomics

The  Division  of  Psychiatric  Genomics  (now  called  Pamela  Sklar  Division  of  Psychiatric  Genomics)  was

established in 2011 by Dr. Pamela Sklar. The mission of the Division is to apply genetic insights to the clinical practice of psychiatry. The Division applies a multidisciplinary approach with a molecular, genomic, and translational focus.

 

About the Icahn Institute for Genomics and Multiscale Biology at ISMMS

The Icahn Institute was founded in 2011 to help advance precision medicine with cutting-edge technologies, novel  partnerships  between the  public  and  private  sector,  and  world-class  computational  and  analytical resources.

 

About the Department of Psychiatry at ISMMS

The Department of Psychiatry at Mount Sinai, a vibrant community of clinicians, researchers, educators, and trainees committed to discovering the causes of and treatments for mental and emotional disorders. We are ranked among the nation’s top psychiatry departments for funding from the National Institutes of Health.

 

About the Friedman Brain Institute at ISMMS

The Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai is one of the world’s premier institutions dedicated to advancing our understanding of brain and spinal cord disorders, and driving innovative approaches to new treatments and diagnostic tests through translational research. We are committed to the best in education, research, and clinical care.

 

About the Icahn School of Medicine at Mount Sinai

The ISMMS is an international leader in medical and scientific training, biomedical research, and patient care. It is the medical school for the Mount Sinai Health System, which includes seven hospital campuses, and has more  than  5,000  faculty  and  nearly  2,000  students,  residents  and  fellows.  Our  unwavering  pursuit  of intellectual exchange, breakthrough research, and multidisciplinary teamwork propels us ever forward in biomedical discoveries and advances. We pursue ideas that often challenge conventional wisdom to revolutionize the practice of medicine and produce dramatically better outcomes for patients.

 

Apply

To be considered for a position in the Functional Neurogenomics Laboratory, please submit a cover letter, CV

and at least two letters of recommendation to panagiotis.roussos {at} mssm.edu.


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