Mount Sinai Careers
The B cell biology Laboratory uses state-of-the-art cellular, molecular and in vivo techniques to address clinically relevant questions related to the regulation of antibody production by B cells. We are particularly interested in the mechanisms whereby innate immune cells facilitate the activation of B cells. We are also analyzing how intestinal B cells generate antibodies to commensal bacteria and how these antibodies shape the composition of the gut microbiota. Our interest extends to intestinal antibody-binding protein such as the mucin 2, which enhances gut homeostasis.