Mount Sinai Careers


New York, New York

Job Description


The Molecular Musculoskeletal is involved in basic research in the field of disability due to paralysis. The research effort is looking at regulation of muscle an:d bone mass in mouse and rat models of nerve transection and spinal cord injury, using biochemistry, cell biology, molecular biology, immunohistochemistry procedures and neuroanatomy. A major objective of the research is to understand efficacy and mechanisms of potential therapeutics to reduce muscle atrophy and bone loss.

This work will involve related academic disciplines encompassing the fields of neuroscience, physiology, biochemistry, cell biology, molecular biology and immunohistochemistry.

Major Duties:

1) Prepares lab for experiments, performs the care of animals (colony maintenance, breeding and genotyping, etc.), as required; '
2) Performs surgeries (e.g., nerve transection, spinal cord transection), performs post operative care (cleaning, wound care, urine expression) and physiological testing (e.g., glucose tolerance testing and muscle physiological testing).
3) Maintains records needed pertinent to animal usage and provides reports on this
information. Documents all animal care in conformance with federal, state and local rules and regulations.·
4) )·Conducts studies to determine efficiency of drugs on muscle and bone; develops data required by the study plan, e.g., conducts literature searches for methods and procedures specified by the principal investigator; assists in planning and developing assays to evaluate experimental methods and techniques; sets up, operates and calibrates instruments and equipment; prepares buffer solutions and other chemical or biological reagents with precisely defined concentrations and conditions; preps animals, administers injections, collects specimens; prepares animal tissue for biochemical analysis and
records instrument readings and a variety ofother observations and outcomes in lab notebooks.
5) Compiles and documents results of experiments and prepares data in format which best
illustrates the results (e.g., worksheet, graphs, tables, etc.);
6) 4) Prepares summaries of techniques and procedures for inclusion in laboratory technical
reports and publications. In consultation with the principal investigator, develops improvements and modifications to established procedures to increase laboratory

efficiency. Performs routine maintenance on laboratory equipment and maintains laboratory in a neat, clean, and orderly manner.


The supervisor of the position is the principal investigator who provides initial direction on the priorities, objectives and/or deadlines for recurring work. New or unusual assignments are usually accompanied with a general background discussion and advice on the location of reference material to use. The incumbent plans and carries out the procedural and technical tasks and independently coordinates their efforts with others within and outside of the unit. The technician exercises initiative in solving technical and procedural problems involving minot changes in priorities, equipment or personnel support, and consults with the supervisor on significant technical or procedural problems such as substantial changes in technical procedures
and equipment or personnel requirements. Completed work is reviewed for technical judgment in ·
executing the work and resolving problems, conformance with policies and accepted scientific practices, and in terms of meeting deadlines and assigned project objectives and requirements.

FACTOR 3: GUIDELINES Level3-3 275 Points

The incumbent works on new projects for which only general guidelines or objectives are available. Objectives or guidelines may have gaps in specificity or completeness. The incumbent uses the guidelines to develop methodologies, plan work activities. The incumbent may exercise judgment in interpreting the intent of the guidelines or in deviating from them as the work progresses. Procedures may not have been previously established, such as research protocols, methodology manuals, technical references, calibration procedures, procedures for collecting, preserving, transporting and receiving specimens.

FACTOR 4: COMPLEXITY Level4-3 150 Points

The incumbent independently carries out defined portions of more comprehensive long range projects or assists with several complex experiments which extend over several months. Assignments are such that there are a number of possible courses of action for planning and executing the work. The incumbent is expected to exercise discretion in choosing the options best suited in accomplishing the assignment in an efficient and technically correct manner; to recognize unusual or unexpected results/conditions; to identify/propose the reason(s) for such results/conditions; and to adjust work methods to accommodate unusual conditions.

FACTOR 5: SCOPE AND EFFECT Level 5-3 150 Points

The assignments are in support of scientific research and are concerned with the accomplishment of experimental research projects or assigned portions thereof to develop specific information. The incumbent is closely involved with all or almost all phases of the experiment and is assigned responsibility for selected phases when the methods, techniques, and procedures are clearly. In the SCI research environment the work is to be closely involved in almost all phases of the scientist's study and have responsibility for selected phases or to conducttest applications of scientific and technical theories when the methods, techniques, and procedures are clearly outlined. The work produced directly affects the accuracy and reliability of the research effort and the design and execution of future research.


Contacts are primarily with personnel within the Research Service, the host Medical Center support personnel (housekeeping and engineering), and other outside investigators who work in a laboratory setting. Occasionally establishes contacts with equipment manufacturers and
contractor personnel.

The purpose of personal contacts is to plan and coordinate work efforts, discuss technical requirements of equipment with manufacturers and resolve problems concerning particular needs of the laboratory; interpret data obtained and explain its purpose and significance; or to order laboratory supplies. The persons contacted are usually working toward a common goal and generally are reasonably cooperative.


The work requires some physical exertion, such as the ability to restrain and lift up to 2 Kg. experimental animals. The job requires agility or dexterity and excellent hand/eye coordination in the performance of agent operations.


Work involves regular exposure to irritant chemicals and low-level radioisotopes; when safety precautions are required, incumbent uses protective clothing and gear such as laboratory coat, gloves, mask and face shields or goggles when appropriate.


Meets the needs of customers while supporting the Medical Center and Service m1sswns. Consistently communicates and treats customers (patients, visitors, volunteers, and all Medical Center staff) in a courteous, tactful, and respectful manner. Provides the customer with consistent information according to established policies and procedures. Handles conflict and problems in dealing with the customer constructively and appropriately.

Protects printed and electronic files containing sensitive data in accordance with the provisions
of the Privacy Act of 1974 and other applicable laws, federal regulations, VA statutes and policy, and VHS&RA policy. Protects the data from unauthorized release or from loss, alteration, or unauthorized deletion. Follows applicable regulations and instructions regarding access to computerized files, release of access codes, etc., as set out in the computer access agreement that the employee signs.
In all aspects of work, the incumbent demonstrates collaboration with colleagues, patients,
families, & health care practitioners in the delivery of patient centered care.

For Clinical Providers
The incumbent encourages and supports patients and families to participate in care and decision
making at the level that they choose to make personal choices related to their care. In all aspects of work, the incumbent demonstrates collaboration with colleagues, patients, families, & health care practitioners in the delivery of patient centered care.

Takes into consideration age and gender specific needs, psychosocial, cultural and spiritual needs
as related to the work unit assigned in order to identify the differences of the various veteran populations which this institution serves, which include:

a) Late Teenage (17-19). Persons in general have normal physical functions and developing lifestyles. Family influence may be more in balance with peer influence. This is the age at which most make a transition to work, college, or independent living. There is a move towards autonomy in the larger world. Future goals are developed and career/work options explored.

b) Young adulthood (20-40). Persons in general have normal physical functions and lifestyles. Person establishes relationships with significant others and is competent to relate to others.
c) Middle age (40-65). Persons may have physical problems and may have changes in lifestyles because children have left home or change in occupation goals. May be developing physical and/or mentally compromising conditions.
d) Older adulthood (65-75). Persons may be adapting to retirement and changing physical abilities. Chronic illness may also develop. May be developing pr
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