Alison Goate’s laboratory in the Departments of Neuroscience and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai (MSSM) in New York City is currently looking for highly skilled and motivated molecular and cell biologists to be the drivers of our efforts to translate the human genetics of Alzheimer’s disease (AD) into effective preventative and therapeutic interventions. Core areas of focus will be translating genetics and human biology observations into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand innate immune modifiers of AD pathogenesis. In particular, the Goate lab concentrates on identifying human genetic variants associated with AD and dissecting the molecular, cellular and tissue-level mechanisms by which these variants and the associated genes (e.g., APOE, TREM2, SPI1/PU.1, MEF2C, MS4A) modulate disease risk, with a major focus on the role of microglial cell function (e.g., phagocytic clearance of cholesterol-rich cellular debris) in the maintenance of brain tissue homeostasis during aging and in disease conditions. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer’s Disease, as well as at other leading US and European academic institutions and biopharmaceutical companies.
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