Strength Through Diversity
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- A postdoctoral position is now available in the laboratory of Dr. Nina Bhardwaj. This opportunity is designed to understanding the modulation of NK cell biology in the tumor microenvironment (TME), and ultimately towards developing approaches that restore both innate and adaptive immunity, in vivo.
Project Goal: Although the survival of advanced melanoma patients (stage IV) has been extended by interventions that reverse T cell exhaustion, we hypothesize that reversal of exhaustion in NK cells will contribute towards the full restoration of immune responses that are required to eliminate melanoma cells. To address this hypothesis, we aim to define the spectrum of NK cell exhaustion in melanoma and identify molecular/protein targets that potentiate NK cell exhaustion. Secondly, we will determine if NK cell exhaustion can be reversed in response to checkpoint blockade inhibition, and identify associated biomarkers. Lastly, we will develop murine models to define and test interventions that reverse NK cell exhaustion. Characterizing NK cell dysfunction in melanoma will be critical towards developing approaches that restore immunity, in vivo.
Interested applicants should forward a cover letter discussing present and future research interests as well as a CV with references.
Essential Job Functions (including but not limited to):
1. Conduct and design experiments under the direction of lab PI.
2. Report to PI research progress and maintain a current knowledge of literature in relevant fields.
3. Maintain good records and contact with collaborators.
4. Nurture collaborative relationships with fellow scientists within the institution, locally, nationally and internationally.
5. Assist in the preparation of and present experimental results at local and national scientific symposia.
6. Summarize experimental data timely and assist in drafting publications under the direction of the PI.
7. Supervise junior research assistants / technicians / students, order laboratory supplies as needed, and perform necessary clean-up and periodic maintenance.
8. Master computer and technical skills necessary for experimental execution as well as data input and analysis.
• PhD in immunology or immune related disciplines.
• Knowledge of basic and advanced immunology and immunological techniques.
• Experience in cellular and molecular techniques required.
• Experience with murine cancer and/or chronic infection models desirable.
• Knowledge and familiarity with murine and human DC isolation and related functional assays
Skills and abilities:
• The candidate is also expected to be highly self-motivated, creative and capable of contributing productively in a team environment.
• Excellent communication skills in written and oral English are essential.