POSTDOCTORAL FELLOW

Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

 
Roles & Responsibilities:
  • Looking for an enthusiastic, motivated early-to-mid level (PGY0-3) postdoctoral fellow with solid foundation in experimental neurobiology to join the laboratory of Dr. Nadejda Tsankova, MD/PhD, as early as September 2019, in the Departments of Pathology and Neuroscience at the Icahn School of Medicine at Mount Sinai, in Manhattan, NYC. 



    The lab’s main research focus is on understanding the cellular and molecular mechanisms driving tumor initiation, migration, and recurrence in glioblastoma, with a particular focus on the role of epigenetics in shaping tumor phenotype. Our model systems include primary patient-derived glioma cell lines and patient-derived orthotopic xenograft mouse models. Through state-of-the-art biochemical and high throughput molecular techniques, we have begun to uncover genetic and epigenetic drivers of glioma stem cell growth and migration in the above models. Some of the commonly used techniques in the Tsankova lab include FACS isolation of glioma stem cell populations from fresh tissues, CRISPR/Cas9 gene editing (knockout), bulk and single cell RNA-seq using the 10X chromium droplet-based technology, chromatin accessibility studies (ATAC-seq), chromatin immunoprecipitation (ChIP), in vitro migration and proliferation assays, in vivo migration analyses in orthotopic xenografts, live cell imaging, and drug screening for new inhibitors of glioma cell migration.

    There are two specific ongoing projects in the lab, in which the post-doctoral fellow is expected to concentrate their immediate effort. The first one is on the role of the Hippo pathway and its downstream effectors YAP-TEAD in glioma growth and migration, and the mechanism of Hippo and EGFR crosstalk in this context. This project builds on recent findings in the lab that the transcription factor TEAD1 drives tumor migration in GBM and is a direct regulator of EGFR (Tome-Garcia et al, Nature Communications 2018). A second, related, project is to characterize the molecular drivers of tumor migration at the genomic, epigenomic, and transcriptomic levels in glioma populations isolated from the infiltrative tumor edge vs. those isolated from the tumor core, both in primary patient samples and in patient-derived xenografts. 

     
Requirements:
  • [BASED ON JOB DESCRIPTION, THE NECESSARY JOB REQUIREMENTS/PREFERENCES—DEGREES, LICENSES, CERTIFICATIONS, ETC.]
 
Strength Through Diversity

The Mount Sinai Health System believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize healthcare delivery together.
 
We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care. 

Explore more about this opportunity and how you can help us write a new chapter in our story! 

Who We Are

Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
 
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals, including Mount Sinai Beth Israel, Mount Sinai Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
 
The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation. 

EOE Minorities/Women/Disabled/Veterans

 

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