POSTDOCTORAL FELLOW

Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

 
Roles & Responsibilities:
  • Due to the complexity and heterogeneity of ASD and lack of a proper human cellular model, animal models, either naturalistic, environmental, pharmacological or genetic, have traditionally been the preferred choice for investigating mechanisms underlying ASD. However, these models have several conceptual and practical limitations for studying human neurodevelopment. The recent advent of patient-specific induced pluripotent stem cells (iPSCs) has allowed researchers to circumvent these obstacles and efficiently complement animal models by establishing human iPSC lines, which capture both the primary genetic lesion and the genetic background of patients and are therefore particularly useful for disorders with complex etiology, where genetic causes are usually multiple and complex. In vitro induction of iPSCs derived from patients into various neuronal and glial cell types, in monolayer cultures or in organoids, provides a powerful new tool to study the cellular and molecular causes of human disorders and test therapeutic strategies in the cell types most affected in these diseases. The Seaver Center has several ongoing programs
    aiming to model different complex neurogenetic disorders associated with ASD including Phelan- McDermid Syndrome, FOXP1 Syndrome and ADNP Syndrome, using iPSCs.

    Duties and Responsibilities:
    Specific responsibilities include: 
    • Performing and supervising iPSC reprogramming 
    • Creating genetically modified lines 
    • Differentiating iPSC in different types of neuronal cells 
    • Neuron phenotyping 
    • RNA sequencing experiments 
    • Collecting, analyzing, and reviewing experimental data for publication and presentation 
    • Leading new experiments and techniques when needed 
    • Supervising students and technicians in the lab. 
    • Perform other duties as required. 

    Performs other related duties.

 Requirements:

  • Education:
    Ph.D. or equivalent in Neuroscience, Neurobiology or a related discipline.

    Experience:
    Experience in cellular neuroscience, cell culture, iPSC reprogramming and differentiation and/or cell transfection.
    • Experience in gene expression manipulation including cell transfection, utilization of viruses, shRNAs, CRISP-Cas9 gene editing.
    • Experience in standard molecular biology techniques
    • Preferred applicants will have additional experience in single cell and multi-electrode array electrophysiology.

    Computer and General Skills:
    • Advanced knowledge of the Microsoft Office and Adobe suites
    • Knowledge in R or other languages for statistical computing or graphics is a plus.
    • Highly motivated.
    • Strong communication and writing skills.
    • Ability to work both independently and in a multidisciplinary team-oriented environment.
    • Strong organizational skills and analytic ability.
Strength Through Diversity

The Mount Sinai Health System believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize healthcare delivery together.
 
We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care. 

Explore more about this opportunity and how you can help us write a new chapter in our story! 

Who We Are

Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
 
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals, including Mount Sinai Beth Israel, Mount Sinai Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
 
The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation. 

EOE Minorities/Women/Disabled/Veterans

 

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