Strength Through Diversity
Ground breaking science. Advancing medicine. Healing made personal.
- A postdoctoral position is now available in the laboratory of Dr. Nina Bhardwaj. This opportunity is designed to understand the immune response to solid and hematologic tumors on diverse populations of lymphoid and myeloid cells. Collectively, these cells function to recognize cancerous cells and eliminate them from the system, followed by resolution and a return to homeostasis. The candidate shall engage studies that provide insight into the mechanisms that underlying recognition and killing of target cells by T lymphocytes. These studies are directly relevant to any drug development effort that relying on to cytotoxic lymphocytes and their functions, including those in the immune-oncology and vaccine-development fields.
Project Goal: The project is focused on the interaction of T lymphocytes and target cancer cells at the level of the TCR:pMHC, and how this relates to cancer cell elimination. The studies shall pay particular attention on projects in the context of a pre-clinical model of murine melanoma. Existing projects that identified and characterized neoantigens, and their cognate TCR(s), as well as those for non-mutated tumor antigens relevant to this model shall be used for future experiments including findings that facilitated studies of the structural basis of the underlying pMHC:TCR interaction in as well as proximal T lymphocyte cell biology underlying cytotoxic effector function. The candidate is expected to continue and improve on low-level mechanistic studies that were extended to tissue-level tumor immunology, and immunotherapy by means of in vivo orthotopic implantation of melanoma cells followed by vaccination and/or adoptive transfer of T lymphocytes engineered to express TCR under study followed by phenotyping by cytometry and transcript-sequencing. Also included are experiments on second-order interactions between T lymphocytes and target tumor cells, or third-order interactions between either cell type and accessory cells (myeloid/lymphoid/ vascular/stromal) performed by genetic and/or pharmacologic manipulation of in vitro or in vivo.
Interested applicants should forward a cover letter discussing present and future research interests as well as a CV with references.
Essential Job Functions (including but not limited to):
1. Conduct and design experiments under the direction of the lab PI.
2. Report to the PI research progress and maintain a current knowledge of literature in relevant fields.
3. Maintain good records and contact with collaborators.
4. Nurture collaborative relationships with fellow scientists within the institution, locally, nationally and internationally.
5. Assist in the preparation of and present experimental results at local and national scientific symposia.
6. Summarize experimental data timely and assist in drafting publications under the direction of the PI.
7. Supervise junior research assistants / technicians / students, order laboratory supplies as needed, and perform necessary clean-up and periodic maintenance.
8. Master computer and technical skills necessary for experimental execution as well as data input and analysis.
• PhD/MD in immunology or immune related disciplines.
• Knowledge of basic and advanced immunology and immunological techniques.
• Experience in cellular and molecular techniques required.
• Experience with murine cancer and/or chronic infection models desirable.
• Knowledge and familiarity with murine and human DC isolation and related functional assays
Skills and abilities:
• The candidate is also expected to be highly self-motivated, creative and capable of contributing productively in a team environment.
• Excellent communication skills