Strength Through Diversity
Ground breaking science. Advancing medicine. Healing made personal.
- We are a young and dynamic research group focused on functional genomics and genetics in the Seaver Autism Center for Research and Treatment in the Departments of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. We are seeking an ambitious, creative, and motivated Postdoctoral Fellow with expertise in computational biology to study mechanisms of RNA editing in mood disorders and neurodevelopmental disorders. The position requires a quantitative statistical background and extensive experience with bioinformatics, genetics, genome data analysis and/or neuroscience. The ideal candidate will have strong biological and statistical background with proven expertise in transcriptomics, including RNA-sequencing and single-cell RNA-sequencing data. Experience in molecular biology and functional validation of disease-associated variants is a plus, but not required.
- The Seaver Center is a fully integrated translational research center dedicated to discovering the biological causes of autism spectrum disorder and other neurodevelopmental disorders and developing breakthrough treatments. Our mission is to bridge the gap between new discoveries at the basic science level and clinical care by developing new and improved approaches to autism diagnosis and treatment. Our interdisciplinary patient-based research team includes psychiatrists, psychologists, a developmental pediatrician,
neurologist, clinical geneticist, and trainees in medicine and psychology. The Seaver Autism Center is committed to serving individuals of all levels of functioning and takes a unique genetics-first approach to autism and neurodevelopmental research.
We offer a 2-year position, renewable up to 5 years, with a competitive salary and benefit package. The candidate will have the opportunity to:
• Conduct cutting-edge research with a strong translational impact for neurodevelopmental disorders and major mood disorders;
• Integrate the neuroscience expertise with genetics and genomics skills and be involved in large-scale genomic studies and take lead on large-scale international consortia data analyses;
• Be an active participant in the vibrant and exciting research community of the Seaver Autism Center and the Pamela Sklar Division of Psychiatric Genomics at the Icahn School of Medicine at Mount Sinai.
• Gain exposure to a wide range of international investigators and collaborators.
• We also offer convenient/affordable housing options for postdoctoral fellows in the vicinity of the laboratory and Central Park on the Upper East Side of Manhattan. Postdocs also receive support from
a dedicated Office of Postdoctoral Affairs.
• Computational investigation of large-scale RNA-sequencing and single-cell RNA-sequencing (scRNAseq) data to uncover disease-related RNA editing events.
• Establishing systems-biology methods and pipelines to integrated large-scale genotypic, RNA editing, splicing and gene expression and proteomic data in health and disease.
• Lead data analysis efforts as a part of large international consortia.
• Develop computational methods that integrate large-scale PheWAS resources.
• Apply and develop new computational tools and methods for identifying/quantifying RNA editing in the human brain and CNS-related cell types.
• Assist in studies applying site-directed RNA editing approaches as therapeutic agents to correct rare mutations that are currently being studied in the Seaver Autism Center for Research and Treatment.
• Assume a major role in the writing of scientific publications, fellowships and grant applications and supervise PhD and MSc students.
- • Academic PhD degree in biotechnology, genetics, statistical genetics, computational biology, neuroscience or areas relevant to the announced position.
• Strong interest in human genetics, genomics and disease. Publication record would be a bonus.
• Strong understanding of biostatistics, bioinformatics and clinical research.
• The applicant must be able to work productively via collaborative interactions with diverse team members working towards common goals.
• The candidate should possess excellent communicating and writing skills in English.