POSTDOCTORAL FELLOW

Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

 
Roles & Responsibilities:
  • Postdoctoral Scholar - Neurodevelopment and Brain Tumors, Tsankova lab:

    Job Description: Looking for an enthusiastic, motivated postdoctoral fellow with both computational and experimental background and interest in neurodevelopment and neuro-oncology to join the laboratory of Dr. Nadejda Tsankova, MD/PhD, in the Departments of Pathology and Neuroscience, at the Icahn School of Medicine at Mount Sinai, Manhattan, NYC.

    The lab’s main research question is to understand how brain tumor (glioma) cells highjack normal neurodevelopmental molecular programs to maintain their malignant cancer stem cell-like phenotype, focusing on the role of epigenetics and transcriptional regulation, with the ultimate goal of uncovering better strategies for reversing malignant tumor growth and spread. 

    There are two parallel, recently NIH-funded, ongoing computational projects, in which the applicant is expected to be involved. The first is the integrated analysis of bulk and single cell transcriptome (RNA-seq) and epigenome (ATAC-seq, HI-C, ChiP-seq) datasets, generated across five stages of normal human neural development, with a strong focus on uncovering the transcriptional footprints driving normal human gliogenesis. Single cell sequencing analysis will be performed in collaboration with the bioinformatics lab of Dr. Alexander Tsankov, who will co-mentor the applicant. The second project builds on our lab’s recent finding for the role of TEAD1 in glioma migration (Tome-Garcia et al, Nature Communications 2018), and will involve further dissection of the transcriptional regulatory network driving tumor stem cell migration and progression in glioblastoma, using a large dataset of bulk and single cell RNA-seq, chromatin accessibility (ATAC-seq) and TEAD1-ChIP-seq datasets in various glioblastoma subtypes derived from primary and recurrent tumor samples. Integrated analysis of the above datasets is focused on defining transcriptionally active chromatin cis regulatory elements and trans TF footprint occupancy in the context of tumor migration and progression. For both projects, experimental validation in organoid models is expected. 

    Some of the commonly used techniques in the Tsankova lab include FACS isolation of neural / glioma stem cell populations from fresh tissues, CRISPR/Cas9 gene editing (knockout), bulk and single cell RNA-seq using the 10X chromium droplet-based technology, chromatin accessibility studies (ATAC-seq), chromatin immunoprecipitation (ChIP), in vitro migration and proliferation assays, in vivo migration analyses in orthotopic xenografts, live cell imaging, and drug screening for new inhibitors of glioma cell migration. Our model systems include primary patient-derived cells / spheroids and orthotopic xenograft mouse models. 

 


 

Requirements:
  • [BASED ON JOB DESCRIPTION, THE NECESSARY JOB REQUIREMENTS/PREFERENCES—DEGREES, LICENSES, CERTIFICATIONS, ETC.]
 
Strength Through Diversity

The Mount Sinai Health System believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize healthcare delivery together.
 
We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care. 

Explore more about this opportunity and how you can help us write a new chapter in our story! 

Who We Are

Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
 
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals, including Mount Sinai Beth Israel, Mount Sinai Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
 
The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation. 

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