Strength Through Diversity
Ground breaking science. Advancing medicine. Healing made personal.
Roles & Responsibilities:
- Proteolysis targeting chimeras (PROTACs) or degraders are bivalent compounds with one moiety that binds an E3 ubiquitin ligase and another moiety that binds the protein target of interest. The induced proximity leads to ubiquitination of the protein target and its subsequent degradation at the proteasome. This technology has been rapidly gaining momentum in the drug discovery field. Dr. Jian Jin’s lab at Icahn School of Medicine at Mount Sinai is a leader in this research field and has developed a number of first-in-class degraders targeting oncogenic proteins. The postdoctoral fellow will participate in research studies, which focus on developing and characterizing novel degraders as anti-cancer therapeutics. The main responsibilities of the postdoctoral fellow include: (1) develop biochemical and cellular assays and characterize biological effects of novel degraders in these assays/cellular systems; (2) evaluate key compounds using biophysical methods such as isothermal titration calorimetry and surface plasmon resonance; (3) conduct mechanistic studies, (4) analyze data and prepare reports for review with the PI and other lab members; (5) document all work according to standard procedures; (6) prepare or contribute to publications and grant applications; (7) prepare and present materials at seminars and meetings; and (8) comply with all safety rules.
Strength Through Diversity
The Mount Sinai Health System believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize healthcare delivery together.
We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care.
Explore more about this opportunity and how you can help us write a new chapter in our story!
Who We Are
Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals, including Mount Sinai Beth Israel, Mount Sinai Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation.