Trainee (Guccione Lab), Oncological Sciences

Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

Roles & Responsibilities:

The field of research for this internship is molecular oncology, specifically we will dissect the role of PRDM15, a novel oncogenic Zn-finger protein, in Hematological malignancies. We aim at

  • Studying the mechanistic role of PRDM15 in driving tumorigenesis (using both in vitro and conditional PRDM15 KO mouse models)
  • Developing tools to inhibit its functions for therapeutic purposes (testing the efficacy of Antisense Oligonucleotides targeting the pre-mRNA of PRDM15 and developing small molecule degraders for PRDM15)

A position is available to highly motivated recent graduates (Bachelor, Masters or MD degree) who will be working as part of a multidisciplinary team, composed of Molecular-, Cancer- and Computational-biologists.


The Trainee is expected to work full time between January and June 2020. The trainee will be supervised by a more senior member of the lab, and will perform molecular biology (e.g. cloning, qPCR, ChIP assays) and molecular oncology experiments (e.g. tissue culture and in vivo models of cancer).

  • Bachelor’s degree in life sciences; masters degree preferred
  • Strong background in Molecular Biology, Epigenetic mechanisms of gene regulation, Genomics or Computational Science is appreciated
  • Experience in primary cells tissue culture and organoid culture (Colon and Liver organoids) is appreciated
  • Experience in working with mouse models of cancer and with stem cell research is preferred
Strength Through Diversity

The Mount Sinai Health System believes that diversity is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize medicine together.


We work hard to acquire and retain the best people, and to create a welcoming, nurturing work environment where you can develop professionally. We share the belief that all employees, regardless of job title or expertise, can make an impact on quality patient care.


Explore more about this opportunity and how you can help us write a new chapter in our story!

Who We Are

Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.


Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.


The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation. 


EOE Minorities/Women/Disabled/Veterans

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