Strength Through Diversity
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- The Costa and Stillitano Labs are seeking a full-time postdoctoral research fellow on a funded project to study the pathophysiology of Phospholamban (PLN) R14del-induced cardiomyopathy. The work relates to characterizing a new transgenic mouse model of the disease, using both in vivo and ex vivo cardiac procedures. Analysis techniques will include molecular biology, biochemistry, histopathology, and microscopy as well as functional assays using cardiac echo and MRI. The project also involves non-cardiac procedures including tail vein injection of vectors and harvesting organs for gene therapy studies.
In addition, the fellow will be involved in areas related to gene editing, human pluripotent stem cells and derived cardiomyocytes with characterization by microelectrode array, calcium imaging, and more traditional molecular analysis.
Daily responsibilities will include, and are not limited to, developing hypotheses, designing and conducting scientific experiments, recording and analyzing data, using modern laboratory based equipment and computer software, and keeping abreast of current scientific literature and relevant studies in the field to learn new analytical techniques.
The successful candidate will present research findings to others within the Cardiovascular Research Center and to our international network of collaborators which may involve domestic and international travel. He/she will participate in weekly laboratory meetings and will also take a lead role in writing and submitting papers resulting from his/her research. Assisting with the submission of proposals for extramural grant funding is expected.
- For this position, an MD or PhD degree is required in addition to prior cardiovascular-related research experience. Experience conducting surgical procedures on mice and/or human stem cell biology is highly desirable.