POSTDOCTORAL FELLOW

Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

 
Roles & Responsibilities:
  • Functional genomics of post-traumatic stress disorder
    Depts. of Psychiatry and Genetics and Genomic Sciences
    Seaver Autism Center for Research and Treatment
    Icahn School of Medicine at Mount Sinai
    New York, NY


    One postdoctoral position is available in the Breen Lab with a primary focus on the application of bulk and single-cell RNA-sequencing technologies to study transgenerational effects of maternal stress on child health and development as well as genomic responses to post-traumatic stress disorder (PTSD) in adults. 

  • As part of the Breen Lab, the postdoctoral candidate will play a major role in the Lab and in the Seaver Autism Center through the application of transcriptomic pipelines and analyses to uncover transcriptional and epigenetic mechanisms associated with PTSD and the transgenerational effects of maternal PTSD. These analyses will be carried out across both brain and blood cells, using human induced pluripotent stem cells (hiPSCs) and peripheral blood immune cells. In addition, the postdoctoral candidate will be responsible for integrating transcriptomic data and large-scale genetic, proteomic and metabolomic data sets that are generated in the laboratory and collected from the public domain. The candidate will work collaboratively with wet-bench biologists and work independently to interpret results and experimentally validate data derived from computational studies. In doing so, we strive to construct biologically plausible mechanistic models of ASD, which we validate both functionally and clinically.

  

Requirements:
  • A strong candidate will be motivated and enthusiastic about understanding the neurobiology of ASD, and will show a wide interest in the work of the Seaver Autism Center. The position will require strong knowledge and understanding of computational biology, bioinformatics, biostatistics and R statistical language. Experience in supercomputing and UNIX environments is advantageous. Individuals without computational experience, but with a molecular biology, neurobiology and/or immunology background and a desire to increase their computational skills are also invited to apply.

    We are a young and dynamic research group focused on functional genomics in the Departments of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai (http://labs.icahn.mssm.edu/breenlab/). Our laboratory is part of the Seaver Autism Center for Research and Treatment and the Pamela Sklar Division of Psychiatric Genomics. The Seaver Center is a fully integrated translational research center dedicated to discovering the biological causes of autism and other neurodevelopmental disorders and developing breakthrough treatments. The mission of the Seaver Center is to bridge the gap between new discoveries at the basic science level and clinical care by developing new and improved approaches to autism diagnosis and treatment. The Pamela Sklar Division of Psychiatric Genomics is focused on understanding the causes, outcomes and treatment of psychiatric disorders using cutting-edge genomic and genetic tools. 

    We offer a 2-year position, renewable up to 5 years, with a competitive salary and benefits package. Salary will be commensurate with years of experience, and is set above the NIH guidelines to counter NYC living expenses. We also offer subsidized housing on the Upper East Side of Manhattan (https://icahn.mssm.edu/education/postdoc/housing). Additional benefits are also offered to parents and carers, including child care, on-site lactation rooms, parent social and support group and financial support with child and dependent care and many others – please find http://icahn.mssm.edu/education/postdoc

    To apply for this position, send the following information to michael.breen@mssm.edu 
    • An up-to-date CV and list of publications, if relevant.
    • Contact names, affiliations and emails for two references. 
 
Strength Through Diversity

The Mount Sinai Health System believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize healthcare delivery together.
 
We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care. 

Explore more about this opportunity and how you can help us write a new chapter in our story! 

Who We Are

Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
 
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals, including Mount Sinai Beth Israel, Mount Sinai Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
 
The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. 

EOE Minorities/Women/Disabled/Veterans

 

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