Strength Through Diversity
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Functional genomics of post-traumatic stress disorder
Depts. of Psychiatry and Genetics and Genomic Sciences
Seaver Autism Center for Research and Treatment
Icahn School of Medicine at Mount Sinai
New York, NY
One postdoctoral position is available in the Breen Lab with a primary focus on the application of bulk and single-cell RNA-sequencing technologies to study transgenerational effects of maternal stress on child health and development as well as genomic responses to post-traumatic stress disorder (PTSD) in adults.
As part of the Breen Lab, the postdoctoral candidate will play a major role in the Lab and in the Seaver Autism Center through the application of transcriptomic pipelines and analyses to uncover transcriptional and epigenetic mechanisms associated with PTSD and the transgenerational effects of maternal PTSD. These analyses will be carried out across both brain and blood cells, using human induced pluripotent stem cells (hiPSCs) and peripheral blood immune cells. In addition, the postdoctoral candidate will be responsible for integrating transcriptomic data and large-scale genetic, proteomic and metabolomic data sets that are generated in the laboratory and collected from the public domain. The candidate will work collaboratively with wet-bench biologists and work independently to interpret results and experimentally validate data derived from computational studies. In doing so, we strive to construct biologically plausible mechanistic models of ASD, which we validate both functionally and clinically.
- A strong candidate will be motivated and enthusiastic about understanding the neurobiology of ASD, and will show a wide interest in the work of the Seaver Autism Center. The position will require strong knowledge and understanding of computational biology, bioinformatics, biostatistics and R statistical language. Experience in supercomputing and UNIX environments is advantageous. Individuals without computational experience, but with a molecular biology, neurobiology and/or immunology background and a desire to increase their computational skills are also invited to apply.
We are a young and dynamic research group focused on functional genomics in the Departments of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai (http://labs.icahn.mssm.edu/breenlab/). Our laboratory is part of the Seaver Autism Center for Research and Treatment and the Pamela Sklar Division of Psychiatric Genomics. The Seaver Center is a fully integrated translational research center dedicated to discovering the biological causes of autism and other neurodevelopmental disorders and developing breakthrough treatments. The mission of the Seaver Center is to bridge the gap between new discoveries at the basic science level and clinical care by developing new and improved approaches to autism diagnosis and treatment. The Pamela Sklar Division of Psychiatric Genomics is focused on understanding the causes, outcomes and treatment of psychiatric disorders using cutting-edge genomic and genetic tools.
We offer a 2-year position, renewable up to 5 years, with a competitive salary and benefits package. Salary will be commensurate with years of experience, and is set above the NIH guidelines to counter NYC living expenses. We also offer subsidized housing on the Upper East Side of Manhattan (https://icahn.mssm.edu/education/postdoc/housing). Additional benefits are also offered to parents and carers, including child care, on-site lactation rooms, parent social and support group and financial support with child and dependent care and many others – please find http://icahn.mssm.edu/education/postdoc
To apply for this position, send the following information to email@example.com
• An up-to-date CV and list of publications, if relevant.
• Contact names, affiliations and emails for two references.