Ground breaking science. Advancing medicine. Healing made personal.
One Research Associate position is available in the Breen Lab with a primary focus on the application of bulk and single-cell RNA-sequencing technologies to study autism and rare monogenic subtypes of autism.
As part of the Breen Lab, the Research Associate will play a major role in the Lab and in the Seaver Autism Center through the application of transcriptomic pipelines and analyses to uncover transcriptional mechanisms associated with autism. These analyses will be carried out across both brain and blood cells, using human induced pluripotent stem cells (hiPSCs) and peripheral blood immune cells. In addition, the research associate will be responsible for integrating transcriptomic data and large-scale genetic, proteomic and metabolomic data sets that are generated in the laboratory and collected from the public domain. The candidate will work collaboratively with wet-bench biologists and work independently to interpret results and experimentally validate data derived from computational studies. In doing so, we strive to construct biologically plausible mechanistic models of ASD, which we validate both functionally and clinically.
- A candidate will be motivated and enthusiastic about understanding the neurobiology of ASD, and will show a wide interest in the work of the Seaver Autism Center
- Basic knowledge and understanding of computational biology, bioinformatics, biostatistics and R statistical language and UNIX environments
- Writes custom scripts for analysis of RNA-sequencing and single-cell RNA-sequencing data
- Uses R, perl and python coding language to gather, store, manipulate and analyze research data
- Designs and implements bioinformatics tools and processes in order to analyze genomic datasets
- Identifies and resolves technical issues and proposes upgrades to current software
- Develops Rshiny applications to host data for a number of independent projects
- Manages databases, conducts statistical and genomic analysis, and participates in the preparation of manuscripts and presentations
- Individuals without computational experience, but with a molecular biology, neurobiology and/or immunology background and a desire to increase their computational skills are also invited to apply
- We are a young and dynamic research group focused on functional genomics in the Departments of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai (http://labs.icahn.mssm.edu/breenlab/)
Our laboratory is part of the Seaver Autism Center for Research and Treatment and the Pamela Sklar Division of Psychiatric Genomics. The Seaver Center is a fully integrated translational research center dedicated to discovering the biological causes of autism and other neurodevelopmental disorders and developing breakthrough treatments. The mission of the Seaver Center is to bridge the gap between new discoveries at the basic science level and clinical care by developing new and improved approaches to autism diagnosis and treatment. The Pamela Sklar Division of Psychiatric Genomics is focused on understanding the causes, outcomes and treatment of psychiatric disorders using cutting-edge genomic and genetic tools.
- Bachelor’s degree in life sciences
- 1-2 years in an academic research setting
- Proficiency is R, Python and Perl
The Mount Sinai Health System believes that diversity is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize medicine together.
We work hard to acquire and retain the best people, and to create a welcoming, nurturing work environment where you can develop professionally. We share the belief that all employees, regardless of job title or expertise, can make an impact on quality patient care.
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Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation.