Postdoctoral Fellow-MSH

Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

Roles & Responsibilities: 

Icahn School of Medicine at Mount Sinai, NYC is seeking to hire a chemistry postdoctoral fellow to staff novel small molecule drug discovery efforts projects in interesting therapeutic areas of unmet medical need including diabetes, orphan disease, neuroscience and oncology.

The role will require the design and synthesis of novel medicinal compounds for testing in in vitro and in vivo assays that support the basic biology and drug discovery research efforts.

The position will allow the candidate to develop valuable new skills and experience in early drug discovery and chemical biology in a highly collaborative research environment. 
These include:
Collaborate to validate novel biological targets
Chemical and biological tool synthesis and development
High throughput screening hit validation and analysis 
Hit and Lead identification
Lead optimization medicinal chemistry and pre-clinical candidate selection
Analysis of in vitro and in vivo activity of compounds (pharmacodynamics)
Optimize physical-chemical properties of drug molecules 
Study Absorption, Distribution, Metabolism and Excretion (ADME) properties
Evaluate drug metabolism and pharmacokinetics (DMPK) in preclinical species
External collaboration and public presentation skills


  • Earned doctorate in organic chemistry with specific experience in total synthesis,  heterocyclic and organometallic chemistry; demonstrated experience in the synthesis, purification, and analysis of complex organic molecules; experience with new method development, rapid analog and library synthesis techniques; multi-step synthetic processes and larger, multi-gram reaction scale-up.  Microwave assisted synthesis.  Excellent reaction trouble shooting skills.  Characterization of new molecules by NMR and MS. Excellent English written and oral communication skills.  Experience with the safe handling of reactive and air-sensitive materials.
Strength Through Diversity

The Mount Sinai Health System believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education and advancement as we revolutionize healthcare delivery together.
We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care. 

Explore more about this opportunity and how you can help us write a new chapter in our story! 

Who We Are

Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals, including Mount Sinai Beth Israel, Mount Sinai Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. 

EOE Minorities/Women/Disabled/Veterans


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